Prenatal exclusion of Norrie's disease.

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Prenatal exclusion of Norrie's disease.

We report on the use of DNA marker probes and linkage analysis to exclude Norrie's disease in the male fetus of a high risk carrier. There are no clinical markers in females carrying the Norrie's disease gene; thus DNA linkage analysis is an essential technique in the management of families 'at-risk' for this severe ophthalmic disease. The principles of DNA linkage are discussed.

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ژورنال

عنوان ژورنال: British Journal of Ophthalmology

سال: 1992

ISSN: 0007-1161

DOI: 10.1136/bjo.76.8.491